Erratum: Primate segmental duplications: crucibles of evolution, diversity and disease
نویسندگان
چکیده
منابع مشابه
Origins and Impacts of Primate Segmental Duplications
Duplicated sequences are substrates for the emergence of new genes and are an important source of genetic instability associated with rare and common disease. Analyses of primate genomes have shown an increase in the proportion of interspersed segmental duplications within the genomes of humans and great apes. This is in contrast to other mammalian genomes that appear to have their recently dup...
متن کاملSerial segmental duplications during primate evolution result in complex human genome architecture.
The human genome is particularly rich in low-copy repeats (LCRs) or segmental duplications (5%-10%), and this characteristic likely distinguishes us from lower mammals such as rodents. How and why the complex human genome architecture consisting of multiple LCRs has evolved remains an open question. Using molecular and computational analyses of human and primate genomic regions, we analyzed the...
متن کاملHow segmental duplications shape our genome: recent evolution of ABCC6 and PKD1 Mendelian disease genes.
The completion of the Human Genome Project has brought the understanding that our genome contains an unexpectedly large proportion of segmental duplications. This poses the challenge of elucidating the consequences of recent duplications on physiology. We have conducted an in-depth study of a subset of segmental duplications on chromosome 16. We focused on PKD1 and ABCC6 duplications because mu...
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The human immunodeficiency viruses (HIV-1 and -2) together with the simian immunodeficiency viruses (SIV) comprise the primate lentivirus family. Since the isolation of the first SIV in 1985 [15], our knowledge of the diversity of these primate lentiviruses has continuously developed by the isolation and characterization of new SIV strains from additional species of African simians. It is now c...
متن کاملComparing genomes with rearrangements and segmental duplications
MOTIVATION Large-scale evolutionary events such as genomic rearrange.ments and segmental duplications form an important part of the evolution of genomes and are widely studied from both biological and computational perspectives. A basic computational problem is to infer these events in the evolutionary history for given modern genomes, a task for which many algorithms have been proposed under v...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2006
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg1997